基因名称：FOXO3 （forkhead box O3）
别名： AF6q21,FKHRL1,FKHRL1P2,FOXO2,FOXO3A
基因ID：2309
Chromosome(GRCh37) ：6 Start: 108881038 End: 109005977 Strand: 1
信号通路：
靶向药：
化疗药：
简介：该基因属于转录因子的叉头家族，具有独特的叉头结构域。该基因可能通过表达细胞死亡所需的基因来触发细胞凋亡。该基因与MLL基因易位与继发性急性白血病有关。另外，还观察到编码相同蛋白质的剪接转录变体。This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.
FOXO3突变与药物：
single nucleotide variant
药物：
Ziv-阿柏西普
疾病：
脉络丛癌
