GALNT14靶向药基因

基因名称:GALNT14  (polypeptide N-acetylgalactosaminyltransferase 14)

别名: GALNT15,GalNac-T10,GalNac-T14
基因ID:79623
Chromosome(GRCh37) :2 Start: 31133331 End: 31361592 Strand:
信号通路:
靶向药:
化疗药:

简介:该基因编码一种高尔基蛋白,是多肽n-乙酰半乳糖氨基转移酶(ppgalnac-ts)蛋白家族的成员。这些酶催化n-乙酰-d-半乳糖胺(galnac)转移到目标肽丝氨酸和苏氨酸上的羟基。编码的蛋白质已经被证明可以将galnac转移到像粘蛋白这样的大蛋白上。这种基因的改变可能在癌症的进展和对化疗的反应中起作用。[由RefSeq提供,2016年6月]This gene encodes a Golgi protein which is a member of the polypeptide N-acetylgalactosaminyltransferase (ppGalNAc-Ts) protein family. These enzymes catalyze the transfer of N-acetyl-D-galactosamine (GalNAc) to the hydroxyl groups on serines and threonines in target peptides. The encoded protein has been shown to transfer GalNAc to large proteins like mucins. Alterations in this gene may play a role in cancer progression and response to chemotherapy. [provided by RefSeq, Jun 2016]
GALNT14突变与药物:

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