GPS2靶向药基因

基因名称:GPS2  (G protein pathway suppressor 2)

别名: AMF-1
基因ID:2874
Chromosome(GRCh37) :17 Start: 7215978 End: 7218658 Strand:
信号通路:
靶向药:
化疗药:

简介:该基因编码一种参与g蛋白丝裂原活化蛋白激酶(mapk)信号级联的蛋白。当该基因在哺乳动物细胞中过度表达时,可能会抑制ras和mapk介导的信号并干扰jnk活性,提示该基因的功能可能是信号抑制。编码蛋白是ncor1-hdac3(核受体辅加压素1-组蛋白脱乙酰基酶3)复合物的一个完整亚单位,研究表明,该复合物通过该亚单位抑制jnk的激活,从而可能为激素介导的ap1(活化蛋白1)功能拮抗提供一种替代机制。[由RefSeq提供,2008年7月]This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]
GPS2突变与药物:

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