基因名称：HDAC8 （histone deacetylase 8）
别名： HD8,WTS,RPD3,CDA07,CDLS5,KDAC8,MRXS6,HDACL1
基因ID：55869
Chromosome(GRCh37) ：X Start: 71549366 End: 71792953 Strand:
信号通路：
靶向药：
化疗药：
简介：组蛋白在转录调控、细胞周期进展和发育事件中起着关键作用。组蛋白乙酰化/去乙酰化改变染色体结构并影响转录因子对dna的获取。该基因编码的蛋白质属于组蛋白脱乙酰酶家族的Ⅰ类。它催化组蛋白n末端末端末端末端赖氨酸残基的脱乙酰化，并抑制具有转录共抑制因子的大型多蛋白复合物中的转录。已发现该基因编码不同亚型的多个转录变体。[由RefSeq提供，2009年10月]Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
HDAC8突变与药物：
