基因名称：HERC2 （HECT and RLD domain containing E3 ubiquitin protein ligase 2）
别名： jdf2,p528,MRT38,SHEP1,D15F37S1
基因ID：8924
Chromosome(GRCh37) ：15 Start: 28356183 End: 28567313 Strand:
信号通路：
靶向药：
化疗药：
简介：该基因属于herc基因家族，编码一组异常大的蛋白质，包含多个结构域。所有成员至少有一个N-末端区域的拷贝，显示与细胞周期调节器RCC1和在一些E3泛素蛋白连接酶中发现的C-末端HECT（与E6-AP C末端同源）域同源。该基因的遗传变异与皮肤/头发/眼睛色素沉着变异有关。该基因的多个假基因位于15号和16号染色体上[由RefSeq提供，2012年3月]This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16. [provided by RefSeq, Mar 2012]
HERC2突变与药物：
