基因名称：HMOX1 （heme oxygenase 1）
别名： HMOX1D,HO-1,HSP32,bK286B10
基因ID：3162
Chromosome(GRCh37) ：22 Start: 35776354 End: 35790207 Strand: 1
信号通路：
靶向药： 索拉非尼
舒尼替尼
化疗药：
简介：血红素加氧酶是血红素分解代谢中的一种重要酶，它将血红素分解成胆绿素，胆绿素还原酶和一氧化碳（一种公认的神经递质）随后将胆绿素转化为胆红素。血红素加氧酶活性是由底物血红素和各种非血红素物质诱导的。血红素加氧酶以2种同工酶、一种诱导性血红素加氧酶-1和一种组成性血红素加氧酶-2的形式存在。hmox1和hmox2属于血红素加氧酶家族。Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family.
HMOX1突变与药物：
EXPRESSION
药物：
索拉非尼
舒尼替尼
疾病：
肾细胞癌
