基因名称:IKBKB (inhibitor of nuclear factor kappa B kinase subunit beta)
别名: IKK2,IKKB,IMD15,IMD15A,IMD15B,NFKBIKB,IKK-beta
基因ID:3551
Chromosome(GRCh37) :8 Start: 42128820 End: 42190171 Strand:
信号通路:
靶向药:
化疗药:
简介:由该基因编码的蛋白质使抑制剂/nf-kappa-b复合物磷酸化,导致抑制剂离解和nf-kappa-b活化。编码的蛋白质本身存在于蛋白质复合物中。已经发现了一些转录变体,有些是蛋白质编码的,有些不是。[由RefSeq提供,2011年9月]The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]
IKBKB突变与药物: