基因名称：IRS2 （insulin receptor substrate 2）
别名： IRS-2
基因ID：8660
Chromosome(GRCh37) ：13 Start: 110406184 End: 110438915 Strand: -1
信号通路： 细胞增殖
能量代谢
靶向药： BMS-754807
化疗药：
简介：该基因编码胰岛素受体底物2，这是一种胞质信号分子，通过充当不同受体酪氨酸激酶和下游效应器之间的分子接头来调节胰岛素、胰岛素样生长因子1和其他细胞因子的作用。这种基因的产物在受体刺激时被胰岛素受体酪氨酸激酶磷酸化，在IL4治疗后被白细胞介素4受体相关激酶磷酸化。This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.
IRS2突变与药物：
AMPLIFICATION
药物：
BMS-754807
疾病：
结直肠癌
