JMJD1C靶向药基因

基因名称:JMJD1C  (jumonji domain containing 1C)

别名: KDM3C,TRIP8,TRIP-8
基因ID:221037
Chromosome(GRCh37) :10 Start: 64926983 End: 65225880 Strand:
信号通路:
靶向药:
化疗药:

简介:这个基因编码的蛋白质与甲状腺激素受体相互作用,包含一个jumonji结构域。它是一种候选的组蛋白去甲基酶,被认为是关键转录因子的协同激活因子。它通过去甲基化dna损伤检测点1(mdc1)蛋白的介体在dna损伤反应途径中发挥作用,是急性髓系白血病生存所必需的。该基因突变与rett综合征和智力障碍有关。选择性剪接导致多个转录变体[由RefSeq提供,2015年12月]The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
JMJD1C突变与药物:

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