基因名称：KEAP1 （kelch like ECH associated protein 1）
别名： INrf2,KLHL19
基因ID：9817
Chromosome(GRCh37) ：19 Start: 10596796 End: 10614054 Strand:
信号通路： 侵袭和转移
靶向药：
化疗药：
简介：该基因编码一个含有kelch-1样结构域的蛋白质，以及一个btb/poz结构域。kelch样ech相关蛋白1以氧化还原敏感的方式与nf-e2相关因子2相互作用，胞浆中的蛋白解离后，nf-e2相关因子2转运到细胞核。这种相互作用导致γ-谷氨酰半胱氨酸合成酶催化亚基的表达。已发现该基因的两个编码相同亚型的选择性剪接转录变体。[由RefSeq提供，2008年7月]This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]
KEAP1突变与药物：
