基因名称:KLLN (killin, p53-regulated DNA replication inhibitor)
别名: CWS4,KILLIN
基因ID:100144748
Chromosome(GRCh37) :10 Start: 89618918 End: 89623194 Strand: -1
信号通路:
靶向药:
化疗药:
简介:这种无内含子基因编码的蛋白质存在于细胞核中,在那里它可以抑制DNA合成,促进S相停滞,并与凋亡相结合。这种DNA结合蛋白的表达被转录因子p53上调。The protein encoded by this intronless gene is found in the nucleus, where it can inhibit DNA synthesis and promote S phase arrest coupled to apoptosis. The expression of this DNA binding protein is upregulated by transcription factor p53.
KLLN突变与药物:
PROMOTER METHYLATION
药物:
Ziv-阿柏西普
疾病:
乳腺癌
肾细胞癌