LRP6靶向药基因

基因名称:LRP6  (LDL receptor related protein 6)

别名: ADCAD2,STHAG7
基因ID:4040
Chromosome(GRCh37) :12 Start: 12268959 End: 12419811 Strand:
信号通路:
靶向药:
化疗药:

简介:该基因编码低密度脂蛋白(ldl)受体基因家族的一个成员。ldl受体是参与受体介导的脂蛋白和蛋白配体内吞的跨膜细胞表面蛋白。该基因编码的蛋白质作为wnt的受体或与frizzled一起作为wnt的共同受体,从而传递典型的wnt/β-catenin信号级联。通过与wnt/beta-catenin信号级联的相互作用,该基因在调节细胞分化、增殖、迁移和多种癌症类型的发展中发挥作用。该蛋白经历伽玛分泌酶依赖的RIP(调节膜内蛋白水解)处理,但切割位点的精确位置尚未确定。[由Refseq提供,2009年12月]This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]
LRP6突变与药物:

常见问题
  • 如何在体龙基因完成所需的检测项目 流程简述 :在线咨询 - 采样送检 - 付款检测 - 检测分析 - 报告结果
查看详情

相关内容

官方客服团队

为您解决烦忧 - 24小时在线 专业服务