基因名称：LRRFIP2 （LRR binding FLII interacting protein 2）
别名： HUFI-2
基因ID：9209
Chromosome(GRCh37) ：3 Start: 37094117 End: 37217992 Strand:
信号通路：
靶向药：
化疗药：
简介：该基因编码的蛋白与myd88结合在toll样受体4（tlr4）的胞浆末端，从而激活核因子kappa b信号传导。泛素样蛋白fat10阻止编码蛋白与tlr4的相互作用，从而使核因子kappa b信号途径失活。此外，这种蛋白可以通过将caspase-1抑制剂flightless-i招募到炎症复合物中来下调nlrp3炎症。[由RefSeq提供，2017年1月]The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq, Jan 2017]
LRRFIP2突变与药物：
