基因名称：MAML1 （mastermind like transcriptional coactivator 1）
别名： Mam1,Mam-1
基因ID：9794
Chromosome(GRCh37) ：5 Start: 179159833 End: 179208035 Strand:
信号通路：
靶向药：
化疗药：
简介：这种蛋白质是人类同源的mastermind，果蝇蛋白，发挥作用的notch信号通路参与细胞命运的决定。有体外证据表明，人类同源物与人类notch受体的细胞内部分形成复合物，可以增加notch诱导基因的表达。这一证据支持其作为notch信号通路中转录辅激活物的功能。[由RefSeq提供，2008年7月]This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway. [provided by RefSeq, Jul 2008]
MAML1突变与药物：
