MAP3K1靶向药基因

基因名称:MAP3K1  (mitogen-activated protein kinase kinase kinase 1)

别名: MEKK,MEKK1,SRXY6,MAPKKK1
基因ID:4214
Chromosome(GRCh37) :5 Start: 56110900 End: 56191979 Strand:
信号通路: 细胞增殖 
免疫相关 
炎症相关 
凋亡抑制
靶向药:
化疗药:

简介:该基因编码的蛋白是丝氨酸/苏氨酸激酶,是一些信号转导通路的一部分,包括erk和jnk激酶途径以及nf-kappa-b途径。编码的蛋白质被自磷酸化激活,需要镁作为其他蛋白质磷酸化的辅助因子。该蛋白具有e3连接酶活性,由植物同源结构域(phd)赋予其n-末端,磷酸激酶活性由激酶结构域赋予其c-末端。[由RefSeq提供,2012年3月]The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012]
MAP3K1突变与药物:

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