基因名称：MAP3K13 （mitogen-activated protein kinase kinase kinase 13）
别名： LZK,MLK,MEKK13
基因ID：9175
Chromosome(GRCh37) ：3 Start: 185000729 End: 185206882 Strand:
信号通路：
靶向药：
化疗药：
简介：该基因编码的蛋白是丝氨酸/苏氨酸蛋白激酶家族的成员。该激酶包含一个双亮氨酸拉链基序，并已证明通过其亮氨酸拉链基序形成二聚体/低聚物。该激酶能磷酸化并激活mapk8/jnk，map2k7/mkk7，提示其在jnk信号通路中的作用。[由RefSeq提供，2008年7月]The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008]
MAP3K13突变与药物：
