基因名称：MAPK8 （mitogen-activated protein kinase 8）
别名： JNK,JNK1,PRKM8,SAPK1,JNK-46,JNK1A2,SAPK1c,JNK21B1/2
基因ID：5599
Chromosome(GRCh37) ：10 Start: 49514682 End: 49647403 Strand:
信号通路：
靶向药：
化疗药：
简介：这个基因编码的蛋白质是MAP激酶家族的一员。MAP激酶作为多种生化信号的整合点，参与细胞增殖、分化、转录调控和发育等多种过程。这种激酶被各种细胞刺激激活，并以特定的转录因子为靶点，从而调节对细胞刺激的即时早期基因表达。肿瘤坏死因子α（TNFα）激活这种激酶是TNFα诱导细胞凋亡所必需的。这种激酶也参与了紫外线辐射诱导的细胞凋亡，被认为与细胞色素c介导的细胞死亡途径有关对该基因的小鼠对应物的研究表明，该激酶在T细胞增殖、凋亡和分化中起关键作用报道了几种编码不同亚型的选择性剪接转录变体[由RefSeq提供，2016年4月]The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]
MAPK8突变与药物：
