MRE11靶向药基因

基因名称:MRE11  (MRE11 homolog, double strand break repair nuclease)

别名: ATLD,HNGS1,MRE11A,MRE11B
基因ID:4361
Chromosome(GRCh37) :11 Start: 94150466 End: 94227040 Strand:
信号通路: 基因组不稳定
靶向药:
化疗药:

简介:该基因编码一种核蛋白,参与同源重组、端粒长度维持和dna双链断裂修复。蛋白质本身具有3’到5’的外切酶活性和内切酶活性。该蛋白与rad50同源物形成复合物;该复合物用于dna末端的非同源连接,并具有增加的单链dna内切酶和3’到5’的外切酶活性。与dna连接酶结合,这种蛋白质在体外利用dna片段末端附近的短同源性促进非完整末端的连接。这个基因在3号染色体上有一个假基因。这个基因的选择性剪接导致两个编码不同亚型的转录变体。[由RefSeq提供,2008年7月]This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3′ to 5′ exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3′ to 5′ exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
MRE11突变与药物:
FRAMESHIFT MUTATION
药物:
奥拉帕利,奥拉帕尼 
疾病:
前列腺癌

LOSS
药物:
他拉唑帕尼 
疾病:
子宫内膜癌

常见问题
  • 如何在体龙基因完成所需的检测项目 流程简述 :在线咨询 - 采样送检 - 付款检测 - 检测分析 - 报告结果
查看详情

相关内容

官方客服团队

为您解决烦忧 - 24小时在线 专业服务