基因名称：MRE11A （MRE11 homolog A, double strand break repair nuclease）
别名： ATLD,HNGS1,MRE11,MRE11B
基因ID：4361
Chromosome(GRCh37) ：11 Start: 94152895 End: 94227074 Strand: -1
信号通路： 细胞周期
靶向药： 他拉唑帕尼
奥拉帕利，奥拉帕尼
化疗药：
简介：该基因编码一种参与同源重组、端粒长度维持和DNA双链断裂修复的核蛋白。该蛋白本身具有3’到5’的核酸外切酶活性和核酸内切酶活性。该蛋白与RAD50同系物形成复合物；该复合物是DNA末端非同源连接所必需的，具有增加的单链DNA内切酶和3’到5’的外切酶活性。该蛋白与DNA连接酶结合，在体外利用靠近DNA片段末端的短同源性促进非完全末端的连接。这个基因在3号染色体上有一个假基因。该基因的选择性剪接导致编码不同亚型的两个转录变体。This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3′ to 5′ exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3′ to 5′ exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
MRE11A突变与药物：
FRAMESHIFT MUTATION
药物：
奥拉帕利，奥拉帕尼
疾病：
前列腺癌
LOSS
药物：
他拉唑帕尼
疾病：
子宫内膜癌
