基因名称:MTF1 (metal regulatory transcription factor 1)
别名: ZRF,MTF-1
基因ID:4520
Chromosome(GRCh37) :1 Start: 38275239 End: 38325292 Strand:
信号通路:
靶向药:
化疗药:
简介:该基因编码一种转录因子,诱导金属硫蛋白和其他参与重金属(如镉、锌、铜和银)稳态的基因表达。该蛋白是一种核质穿梭蛋白,在重金属暴露后积聚在细胞核中,并与含有金属反应元件(MRE)的启动子结合[由RefSeq提供,2008年7月]This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE). [provided by RefSeq, Jul 2008]
MTF1突变与药物: