基因名称：NDUFA13 （NADH:ubiquinone oxidoreductase subunit A13）
别名： B16.6,CDA016,CGI-39,GRIM19,GRIM-19,MC1DN28
基因ID：51079
Chromosome(GRCh37) ：19 Start: 19626550 End: 19639858 Strand:
信号通路：
靶向药：
化疗药：
简介：该基因编码线粒体膜呼吸链nadh脱氢酶（复合物i）的一个亚单位，其功能是将电子从nadh转移到呼吸链。该蛋白是复合物I组装和电子转移活性所必需的该蛋白结合信号转导和转录激活因子3（STAT3）转录因子，可作为肿瘤抑制因子发挥作用。从线粒体纯化的人蛋白迁移约16 kDa。已经发现来自上游启动子并且能够表达具有较长n末端的蛋白质的转录物，但是它们的生物学有效性尚未确定。[由RefSeq提供，2009年10月]This gene encodes a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain. The protein is required for complex I assembly and electron transfer activity. The protein binds the signal transducers and activators of transcription 3 (STAT3) transcription factor, and can function as a tumor suppressor. The human protein purified from mitochondria migrates at approximately 16 kDa. Transcripts originating from an upstream promoter and capable of expressing a protein with a longer N-terminus have been found, but their biological validity has not been determined. [provided by RefSeq, Oct 2009]
NDUFA13突变与药物：
