基因名称：NEDD9 （neural precursor cell expressed, developmentally down-regulated 9）
别名： CAS-L,CAS2,CASL,CASS2,HEF1
基因ID：4739
Chromosome(GRCh37) ：6 Start: 11183531 End: 11382581 Strand: -1
信号通路：
靶向药：
化疗药：
简介：该基因编码的蛋白质是CRK相关底物家族的成员。这个家族的成员是粘附对接分子，它介导信号转导途径的蛋白质-蛋白质相互作用。这种蛋白是一种局灶性粘附蛋白，在细胞附着、迁移和侵袭以及细胞凋亡和细胞周期中起着重要的调控信号复合物的作用。这种蛋白也被报道在癌症转移中起作用。选择性剪接导致多个转录变体。The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants.
NEDD9突变与药物：
EXPRESSION
药物：
Ziv-阿柏西普
疾病：
肝细胞癌
