基因名称：NFATC4 （nuclear factor of activated T cells 4）
别名： NFAT3,NF-AT3,NF-ATC4
基因ID：4776
Chromosome(GRCh37) ：14 Start: 24834885 End: 24848810 Strand:
信号通路：
靶向药：
化疗药：
简介：该基因编码活化T细胞（NFAT）蛋白家族的核因子编码的蛋白质是dna结合转录复合物的一部分。该复合物由至少两个组成部分：在T细胞受体刺激和易感性核成分上易位到细胞核的预先存在的胞质成分。NFAT蛋白被钙调素依赖性磷酸酶钙调神经磷酸酶激活。编码蛋白在t细胞中诱导表达细胞因子基因，特别是在诱导白细胞介素-2和白细胞介素-4中起作用。选择性剪接导致多个转录变体[由RefSeq提供，2014年1月]This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
NFATC4突变与药物：
