NKAP靶向药基因

基因名称:NKAP  (NFKB activating protein)

别名:
基因ID:79576
Chromosome(GRCh37) :X Start: 119059013 End: 119077735 Strand:
信号通路:
靶向药:
化疗药:

简介:该基因编码一种参与普遍存在的转录因子nf-kappab激活的蛋白质。该蛋白和组蛋白去乙酰化酶HDAC3和Notch共加压因子复合物相关,从而充当Notch靶基因的转录抑制因子它也是αβT细胞发育所必需的在x染色体上发现了一个相关的假基因,而在6号染色体上发现了一个相关的无内含子的逆转录酶,该逆转录酶具有完整的cds并且可能具有功能。[由RefSeq提供,2010年5月]This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6. [provided by RefSeq, May 2010]
NKAP突变与药物:

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