基因名称:NLRC3 (NLR family CARD domain containing 3)
别名: NOD3,CLR16.2
基因ID:197358
Chromosome(GRCh37) :16 Start: 3589033 End: 3627392 Strand:
信号通路:
靶向药:
化疗药:
简介:这个基因编码一个NOD样受体家族成员编码蛋白是先天免疫的胞质调节因子。该蛋白直接与干扰素基因刺激因子(sting)相互作用,以防止其适当的转运,导致sting依赖性激活的先天免疫反应中断。选择性剪接导致多个转录变体[由RefSeq提供,2014年2月]This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption of STING-dependent activation of the innate immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
NLRC3突变与药物: