基因名称:NRG1 (neuregulin 1)
别名: ARIA,GGF,GGF2,HGL,HRG,HRG1,HRGA,MST131,MSTP131,NDF,NRG1-IT2,SMDF
基因ID:3084
Chromosome(GRCh37) :8 Start: 31496902 End: 32622548 Strand: 1
信号通路:
靶向药: 阿法替尼
Anti-ERBB3 Agents AV-203
西妥昔单抗
厄洛替尼
帕妥珠单抗
GSK2849330
拉帕替尼
Patritumab
化疗药:卡铂 顺铂 吉西他滨 紫杉醇
简介:该基因编码的蛋白质是一种膜糖蛋白,可调节细胞信号传导,并在多器官系统的生长和发育中起到关键作用。通过选择性启动子的使用和剪接,该基因产生了一种不同亚型的特殊变体。这些亚型以组织特异性的方式表达,在结构上有显著差异,分为I型、II型、III型、IV型、V型和VI型。这种基因的失调与癌症、精神分裂症和双相情感障碍(BPD)等疾病有关。The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).
NRG1突变与药物:
EXPRESSION
药物:
Anti-ERBB3 Agents AV-203
卡铂 西妥昔单抗
顺铂 吉西他滨 拉帕替尼
紫杉醇 Patritumab 疾病:
乳腺癌
癌症 结直肠癌
头颈部鳞状细胞癌 非小细胞肺癌 卵巢癌
SDC4-NRG1
药物:
阿法替尼
疾病:
肺腺癌
SLC3A2-NRG1
药物:
Ziv-阿柏西普
疾病:
肺腺癌
ATP1B1-NRG1 fusion
药物:
阿法替尼
疾病:
“胆管癌”
NRG1 fusion
药物:
阿法替尼
Erlotinib/Pertuzumab GSK2849330
疾病:
“粘液腺癌”,“胰腺腺癌”