基因名称：NT5E （5′-nucleotidase ecto）
别名： CALJA,CD73,E5NT,NT,NT5,NTE,eN,eNT
基因ID：4907
Chromosome(GRCh37) ：6 Start: 86159809 End: 86205500 Strand: 1
信号通路：
靶向药： 西妥昔单抗
化疗药：
简介：该基因编码的蛋白是一种质膜蛋白，催化胞外核苷酸转化为膜渗透性核苷。编码蛋白被用作淋巴细胞分化的决定因素。这种基因的缺陷会导致关节和动脉钙化。两个编码不同亚型的转录变体已经被发现。The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.
NT5E突变与药物：
OVEREXPRESSION
药物：
西妥昔单抗
疾病：
结直肠癌
