基因名称:PALB2 (partner and localizer of BRCA2)
别名: FANCN,PNCA3
基因ID:79728
Chromosome(GRCh37) :16 Start: 23614488 End: 23652631 Strand: -1
信号通路: 基因组不稳定
遗传相关
靶向药: 丝裂霉素C
奥拉帕利,奥拉帕尼
化疗药:
简介:这个基因编码一种可能抑制肿瘤的蛋白质。这种蛋白与乳腺癌2早发蛋白(BRCA2)在核病灶结合并与之共定位,可能允许BRCA2稳定的核内定位和积累。
This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2.
PALB2突变与药物:
BIALLELIC INACTIVATION
药物:
丝裂霉素C
奥拉帕利,奥拉帕尼
疾病:
胰腺癌
前列腺癌
L531FS*30
药物:
Ziv-阿柏西普
疾病:
“乳腺癌”