基因名称：PDE1C （phosphodiesterase 1C）
别名： Hcam3,DFNA74,hCam-3,cam-PDE1C
基因ID：5137
Chromosome(GRCh37) ：7 Start: 31791666 End: 32339016 Strand:
信号通路：
靶向药：
化疗药：
简介：这个基因编码一种属于3’5′-环核苷酸磷酸二酯酶家族的酶。这个家族的成员催化环核苷酸、环磷酸腺苷和环磷酸鸟苷水解成相应的核苷5′-单磷酸该基因编码的酶调节血管平滑肌细胞的增殖、迁移和内膜增生这种酶还通过调节生长因子受体（如PDGF受体β）的稳定性在病理性血管重塑中发挥作用[由RefSeq提供，2016年7月]This gene encodes an enzyme that belongs to the 3’5′-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5′-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta. [provided by RefSeq, Jul 2016]
PDE1C突变与药物：
