基因名称:PDE4D (phosphodiesterase 4D)
别名: DPDE3,PDE43,STRK1,ACRDYS2,HSPDE4D,PDE4DN2
基因ID:5144
Chromosome(GRCh37) :5 Start: 58264865 End: 59783925 Strand:
信号通路:
靶向药:
化疗药:
简介:这个基因编码四个哺乳动物对应的果蝇“dunce”基因中的一个。编码蛋白具有3’,5′-环腺苷酸磷酸二酯酶活性,降解camp,在多种细胞类型中充当信号转导分子。该基因使用不同的启动子产生多个交替剪接的转录变体,编码功能蛋白。[由RefSeq提供,2009年9月]This gene encodes one of four mammalian counterparts to the fruit fly ‘dunce’ gene. The encoded protein has 3′,5′-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]
PDE4D突变与药物: