PDK1靶向药基因

基因名称:PDK1  (pyruvate dehydrogenase kinase 1)

别名:
基因ID:5163
Chromosome(GRCh37) :2 Start: 173420101 End: 173490351 Strand:
信号通路: 细胞增殖 
凋亡抑制
靶向药:
化疗药:

简介:丙酮酸脱氢酶(pdh)是一种催化丙酮酸氧化脱羧的线粒体多酶复合物,是哺乳动物体内调节碳水化合物燃料稳态的主要酶之一。酶活性由磷酸化/去磷酸化循环调节。丙酮酸脱氢酶激酶(pdk)磷酸化pdh导致失活。已发现该基因的多个选择性剪接转录变体。[由RefSeq提供,2013年6月]Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013]
PDK1突变与药物:

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