基因名称：PLCB1 （phospholipase C beta 1）
别名： PLC-I,EIEE12,PI-PLC,PLC154,PLCB1A,PLCB1B,PLC-154,PLC-beta-1
基因ID：23236
Chromosome(GRCh37) ：20 Start: 8112912 End: 8865547 Strand:
信号通路：
靶向药：
化疗药：
简介：该基因编码的蛋白质催化磷脂酰肌醇4，5-二磷酸形成肌醇1，4，5-三磷酸和二酰甘油这种反应以钙为辅助因子，在许多细胞外信号的细胞内转导中起重要作用。这个基因被两个G蛋白α亚单位α-Q和α-11激活。已经发现了两个编码不同亚型的转录变体。[由RefSeq提供，2008年7月]The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PLCB1突变与药物：
