基因名称:POLE4 (polymerase (DNA) epsilon 4, accessory subunit)
别名: YHHQ1,p12
基因ID:56655
Chromosome(GRCh37) :2 Start: 75185619 End: 75197255 Strand: 1
信号通路:
靶向药: 派姆单抗(帕博利珠单抗)
化疗药:
简介:pole4是一种组蛋白折叠蛋白,与其他组蛋白折叠蛋白相互作用,以序列独立的方式结合DNA。这些组蛋白折叠蛋白二聚体结合在较大的酶复合物中,用于DNA转录、复制和包装。POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.
POLE4突变与药物:
A59E
药物:
派姆单抗(帕博利珠单抗)
疾病:
肺腺癌