基因名称：PPP2R1A （protein phosphatase 2 scaffold subunit Aalpha）
别名： MRD36,PP2AA,PR65A,PP2AAALPHA,PP2A-Aalpha
基因ID：5518
Chromosome(GRCh37) ：19 Start: 52693055 End: 52729678 Strand:
信号通路： 细胞增殖
炎症相关
能量代谢
肿瘤干细胞
靶向药：
化疗药：
简介：该基因编码蛋白质磷酸酶2的恒定调节亚单位。蛋白磷酸酶2是四种主要的ser/thr磷酸酶之一，与细胞生长和分裂的负调控有关。它由一种常见的异聚核心酶组成，由一个催化亚基和一个恒定的调节亚基组成，与多种调节亚基相结合。恒定调节亚基a充当支架分子，以协调催化亚基和可变调节b亚基的组装。该基因编码恒定调节亚单位a的α亚型。已描述了选择性剪接的转录变体。[由RefSeq提供，2010年4月]This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
PPP2R1A突变与药物：
