基因名称：PRAM1 （PML-RARA regulated adaptor molecule 1）
别名： PRAM-1,PML-RAR
基因ID：84106
Chromosome(GRCh37) ：19 Start: 8554940 End: 8567538 Strand:
信号通路：
靶向药：
化疗药：
简介：该基因编码的蛋白类似于fyn结合蛋白（fyb/slap-130），一种参与t细胞受体介导的信号转导的衔接蛋白。该基因在正常骨髓生成过程中表达和调节。该基因的表达由维甲酸诱导，并被pml-raralpha、早幼粒细胞白血病（pml）融合蛋白和维甲酸受体α（raralpha）的表达所抑制。[由RefSeq提供，2008年7月]The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha). [provided by RefSeq, Jul 2008]
PRAM1突变与药物：
