基因名称:PRDM1 (PR domain 1)
别名: BLIMP1,PRDI-BF1
基因ID:639
Chromosome(GRCh37) :6 Start: 106534195 End: 106557814 Strand: 1
信号通路: 基因组不稳定
靶向药:
化疗药:
简介:这个基因编码一种蛋白质,作为β-干扰素基因表达的抑制剂。该蛋白与β-干扰素基因启动子的prdi(阳性调节域i元件)特异性结合。这种基因的转录随着病毒的诱导而增加。已经报道了两种编码不同亚型的选择性剪接转录变体。This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported.
PRDM1突变与药物:
MUTATION
药物:
Ziv-阿柏西普
疾病:
弥漫性大B细胞淋巴瘤