PRKAA1靶向药基因

基因名称:PRKAA1  (protein kinase AMP-activated catalytic subunit alpha 1)

别名: AMPK,AMPKa1
基因ID:5562
Chromosome(GRCh37) :5 Start: 40759481 End: 40798297 Strand:
信号通路:
靶向药:
化疗药:

简介:该基因编码的蛋白属于ser/thr蛋白激酶家族它是5′-原AMP活化蛋白激酶(AMPK)的催化亚单位。ampk是一种保存在所有真核细胞中的细胞能量传感器。ampk的激酶活性被提高细胞amp/atp比值的刺激激活。AMPK通过磷酸化调节许多关键代谢酶的活性它通过关闭消耗ATP的生物合成途径,保护细胞免受导致ATP消耗的压力另外,还观察到编码不同亚型的剪接转录变体。[由RefSeq提供,2008年7月]The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5′-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
PRKAA1突变与药物:

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