基因名称：PRKCI （protein kinase C iota）
别名： PKCI,DXS1179E,nPKC-iota
基因ID：5584
Chromosome(GRCh37) ：3 Start: 169940220 End: 170023770 Strand:
信号通路： 细胞增殖
肿瘤干细胞
靶向药：
化疗药：
简介：该基因编码丝氨酸/苏氨酸蛋白激酶蛋白激酶c（pkc）家族的一个成员。pkc家族至少由8个成员组成，它们是差异表达的，参与多种细胞过程。这种蛋白激酶不依赖钙和磷脂。它不被佛波酯或甘油二酯激活。这种激酶可以通过与小gtpase rab2的直接相互作用被募集到囊泡管簇（vtcs），在那里这种激酶磷酸化甘油醛-3-磷酸脱氢酶（gapd/gapdh），并在早期分泌途径中的微管动力学中发挥作用。这种激酶被认为是bcl-abl介导的抗药物诱导凋亡所必需的，因此可以保护白血病细胞免受药物诱导的凋亡。在x染色体上有一个外显子假基因。This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]
PRKCI突变与药物：
