基因名称：PTGS1 （prostaglandin-endoperoxide synthase 1）
别名： COX1,COX3,PHS1,PCOX1,PES-1,PGHS1,PTGHS,PGG/HS,PGHS-1
基因ID：5742
Chromosome(GRCh37) ：9 Start: 125132809 End: 125157982 Strand:
信号通路：
靶向药：
化疗药：
简介：这是编码类似酶的两个基因之一，这些酶催化花生酸盐转化为前列腺素。编码的蛋白调节内皮细胞的血管生成，并被阿司匹林等非甾体抗炎药抑制。基于其作为环氧合酶和过氧化物酶的功能，编码的蛋白质已被鉴定为兼职蛋白。该蛋白可能在肿瘤发展过程中促进细胞增殖。选择性剪接导致多个转录变体[由RefSeq提供，2014年1月]This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
PTGS1突变与药物：
