基因名称：PTPRK （protein tyrosine phosphatase receptor type K）
别名： R-PTP-kappa
基因ID：5796
Chromosome(GRCh37) ：6 Start: 128289924 End: 128841870 Strand:
信号通路：
靶向药：
化疗药：
简介：该基因编码的蛋白是蛋白酪氨酸磷酸酶（PTP）家族的一员众所周知，PTPs是调节细胞生长、分化、有丝分裂周期和癌基因转化等多种细胞过程的信号分子该ptp具有胞外区、单个跨膜区和两个串联催化结构域，因此代表一种受体型ptp。细胞外区域包含一个meprin-a5抗原ptp mu（mam）结构域、一个ig样结构域和四个纤维粘连蛋白iii型重复序列。ptp介导了细胞间的亲和力相互作用，可能是通过与粘附连接处的β-和γ连环蛋白的相互作用。TGF-β1可刺激该基因的表达，这可能对抑制角质形成细胞的增殖具有重要意义[由RefSeq提供，2008年7月]The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]
PTPRK突变与药物：
