RARB靶向药基因

基因名称：RARB  （retinoic acid receptor beta）

别名： HAP,RRB2,NR1B2,MCOPS12,RARbeta1
基因ID：5915
Chromosome(GRCh37) ：3　Start:　25215638　End:　25639423　Strand:
信号通路：
靶向药：
化疗药：

简介：这个基因编码维甲酸受体β，它是核转录调控因子甲状腺类固醇激素受体超家族的成员。这种受体定位于细胞质和亚核室。它与维生素a的生物活性形式维甲酸结合，维甲酸介导胚胎形态发生、细胞生长和分化的细胞信号。人们认为这种蛋白质通过调节基因表达来限制许多细胞类型的生长。该基因首先在一个肝细胞癌中被发现，它位于乙型肝炎病毒整合位点的两侧。交替启动子的使用和差异剪接导致多个转录变体。[由RefSeq提供，2014年3月]This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014]
RARB突变与药物：