基因名称：RELA （RELA proto-oncogene, NF-kB subunit）
别名： p65,CMCU,NFKB3
基因ID：5970
Chromosome(GRCh37) ：11 Start: 65421067 End: 65430443 Strand:
信号通路：
靶向药：
化疗药：
简介：nf-kappa-b是一种广泛存在的转录因子，参与多种生物学过程。它被特定的抑制剂以非活性状态保存在细胞质中。当抑制剂降解时，nf-kappa-b移向细胞核并激活特定基因的转录。nf-kappa-b由结合到rel、rela或relb的nfkb1或nfkb2组成。nf-kappa-b最丰富的形式是nfkb1与该基因的产物rela复合。已经发现了四个编码不同亚型的转录变体。[由RefSeq提供，2011年9月]NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
RELA突变与药物：
