基因名称：RFC4 （replication factor C subunit 4）
别名： A1,RFC37
基因ID：5984
Chromosome(GRCh37) ：3 Start: 186507681 End: 186524484 Strand:
信号通路：
靶向药：
化疗药：
简介：DNA聚合酶delta和DNA聚合酶epsilon对DNA模板的延伸需要辅助蛋白增殖细胞核抗原（PCNA）和复制因子C（RFC）rfc，又称激活因子1，是一种由140、40、38、37和36kd五个不同亚基组成的蛋白质复合物。这个基因编码37kd亚单位。该亚单位与36和40kDa亚单位形成核心复合物。核心复合物具有DNA依赖的atp酶活性，PCNA在体外系统中可刺激atp酶活性已经报道了编码相同蛋白质的选择性剪接转录变体。[由RefSeq提供，2008年7月]The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
RFC4突变与药物：
