基因名称:RIT1 (Ras like without CAAX 1)
别名: NS8,RIBB,RIT,ROC1
基因ID:6016
Chromosome(GRCh37) :1 Start: 155867599 End: 155881195 Strand: -1
信号通路:
靶向药: Pictilisib
司美替尼
化疗药:
简介:该基因编码ras相关GTPase亚家族的一个成员。编码蛋白参与调节与细胞应激相关的p38 mapk依赖性信号级联。该蛋白还与神经生长因子协同促进神经元的发育和再生。交替剪接导致多个转录变体。This gene encodes a member of a subfamily of Ras-related GTPases. The encoded protein is involved in regulating p38 MAPK-dependent signaling cascades related to cellular stress. This protein also cooperates with nerve growth factor to promote neuronal development and regeneration. Alternate splicing results in multiple transcript variants.
RIT1突变与药物:
OVEREXPRESSION
药物:
Ziv-阿柏西普
疾病:
子宫内膜癌
MUTATION
药物:
Pictilisib
Selumetinib (AZD6244) 疾病:
肺腺癌