基因名称:ROCK2 (Rho associated coiled-coil containing protein kinase 2)
别名: ROCK-II
基因ID:9475
Chromosome(GRCh37) :2 Start: 11319894 End: 11484711 Strand:
信号通路:
靶向药:
化疗药:
简介:该基因编码的蛋白质是一种丝氨酸/苏氨酸激酶,调节胞质分裂、平滑肌收缩、肌动蛋白应力纤维和局灶性粘连的形成以及c-fos血清反应元件的激活这种蛋白质是ROCK1的一种同工酶,是小GTPase Rho的靶标[由RefSeq提供,2008年7月]The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]
ROCK2突变与药物: