基因名称：RPS6 （ribosomal protein S6）
别名： S6
基因ID：6194
Chromosome(GRCh37) ：9 Start: 19375713 End: 19380252 Strand: -1
信号通路：
靶向药： 依维莫司
化疗药：
简介：核糖体是催化蛋白质合成的细胞器，由一个小的40S亚单位和一个大的60S亚单位组成。这些亚单位由4种RNA和大约80种结构不同的蛋白质组成。这个基因编码一种细胞质核糖体蛋白，它是40S亚单位的组成部分。该蛋白属于核糖体蛋白的S6E家族。是核糖体中蛋白激酶的主要底物，五个C端丝氨酸残基的亚群被不同的蛋白激酶磷酸化。磷酸化是由多种刺激物诱导的，包括生长因子、肿瘤促进剂和有丝分裂原。生长停滞时发生去磷酸化。该蛋白可通过选择性翻译特定类别的mRNA来帮助控制细胞的生长和增殖。与编码核糖体蛋白的基因一样，该基因有多个经过处理的假基因散布在基因组中。Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
RPS6突变与药物：
PHOSPHORYLATION
药物：
依维莫司
疾病：
胃腺癌
