RPS6KA3靶向药基因

基因名称:RPS6KA3  (ribosomal protein S6 kinase A3)

别名: CLS,RSK,HU-3,RSK2,MRX19,ISPK-1,p90-RSK2,pp90RSK2,MAPKAPK1B,S6K-alpha3
基因ID:6197
Chromosome(GRCh37) :X Start: 20168029 End: 20285523 Strand:
信号通路:
靶向药:
化疗药:

简介:该基因编码丝氨酸/苏氨酸激酶rsk(核糖体s6激酶)家族的一个成员。该激酶包含2个不同的激酶催化结构域,并磷酸化各种底物,包括丝裂原活化激酶(MAPK)信号通路的成员这种蛋白的活性与控制细胞的生长和分化有关。该基因突变与coffin-lowry综合征(cls)有关。[由RefSeq提供,2008年7月]This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008]
RPS6KA3突变与药物:

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