基因名称:RRM1 (ribonucleotide reductase catalytic subunit M1)
别名: R1,RIR1,RR1
基因ID:6240
Chromosome(GRCh37) :11 Start: 4115937 End: 4160106 Strand: 1
信号通路:
靶向药: Cisplatine PLATINUM
化疗药:顺铂 多西他赛 吉西他滨 吉西他滨 顺铂 紫杉醇 长春瑞滨
简介:这个基因编码核糖核苷酸还原酶的大的催化亚单位,这是一种将核糖核苷酸转化为脱氧核糖核苷酸所必需的酶。在细胞周期的S阶段以及多个DNA修复过程中,可用的脱氧核糖核苷酸池对DNA复制很重要。选择性剪接导致多个转录变体。This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants.
RRM1突变与药物:
UNDEREXPRESSION
药物:
顺铂 Cisplatine 多西他赛 吉西他滨 Gemcitabine/cisplatin 紫杉醇 PLATINUM 长春瑞滨 疾病:
非小细胞肺癌 胰腺癌
OVEREXPRESSION
药物:
吉西他滨 疾病:
胰腺癌