基因名称：RRM2 （ribonucleotide reductase regulatory subunit M2）
别名： R2,RR2,RR2M
基因ID：6241
Chromosome(GRCh37) ：2 Start: 10262455 End: 10271545 Strand: 1
信号通路：
靶向药：
化疗药：吉西他滨
简介：这个基因编码核糖核苷酸还原酶的两个不相同亚单位之一。这种还原酶催化核糖核苷酸形成脱氧核糖核苷酸。编码蛋白（m2）的合成以细胞周期依赖性方式调节。该基因的转录可以从替代启动子启动，这导致两种亚型的长度不同的N末端。在1号染色体和X号染色体上发现了相关的假基因。This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X.
RRM2突变与药物：
OVEREXPRESSION
药物：
吉西他滨 疾病：
胰腺癌
