基因名称：RUNX1T1 （RUNX1 partner transcriptional co-repressor 1）
别名： CDR,ETO,MTG8,AML1T1,ZMYND2,CBFA2T1,AML1-MTG8
基因ID：862
Chromosome(GRCh37) ：8 Start: 92967195 End: 93115454 Strand:
信号通路： 基因组不稳定
靶向药：
化疗药：
简介：该基因编码髓样易位基因家族的一个成员，该家族与dna结合的转录因子相互作用，并招募一系列的共加压因子以促进转录抑制。t（8；21）（q22；q22）易位是急性髓系白血病最常见的核型异常之一。该易位产生一个嵌合基因，由runt相关转录因子1基因的5’区与该基因的3’区融合而成。该嵌合蛋白被认为与核共加压素/组蛋白脱乙酰酶复合物有关，以阻止造血分化。选择性剪接导致多个转录变体。[由RefSeq提供，2010年11月]This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5′-region of the runt-related transcription factor 1 gene fused to the 3′-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
RUNX1T1突变与药物：
